| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
Smart Carriers for Bioactive Molecules and Cells(의료용 고분자 부문위원회) |
| 제목 |
Viral gene delivery for tissue regenerative medicine |
| 초록 |
Stem cells have significant promise for regenerative medicine, but they first require an understanding of cues that can regulate their behaviors. Delivery of genes capable of regulating stem cell function can serve as an effective means to both investigate biology and to control cell fate for therapeutic applications. Obstacles to such applications continue to be the development of efficient and safe gene delivery vectors. Adeno-associated viral vectors have significant promise as therapeutic vectors due to their safety and delivery efficiency. Unfortunately, no natural AAV variants have been developed to infect stem cells efficiently. Engineering AAV to overcome rate limiting steps in stem cell transduction may have a high impact for stem cell investigations. In this presentation, powerful tools to create de novo bio-inspired nanoparticles that can significantly enhance the capabilities of gene delivery in stem cells, primarily for tissue engineering applications, will be introduced. |
| 저자 |
장재형 |
| 소속 |
연세대 |
| 키워드 |
adeno-associated virus; tissue engineering; stem cell
|
| E-Mail |
|
