| 학회 |
한국화학공학회 |
| 학술대회 |
2017년 가을 (10/25 ~ 10/27, 대전컨벤션센터) |
| 권호 |
23권 2호, p.1705 |
| 발표분야 |
생물화공 |
| 제목 |
Enhanced Production of 1-propanol by metabolically engineered amino acid overproducing Escherichia coli |
| 초록 |
In this study, we suggest a novel 1-propanol biosynthetic pathway by further engineering of L-threonine overproducing Escherichia coli strain that we have previously developed. In this study, the L-threonine overproducing E. coli TH20 strain which we developed in a past study was selected as basic strain. E. coli TH20 was further engineered for producing 1-propanol. In silico flux response analysis for the carbon source optimization followed by deletion of competing pathway successfully generated an E. coli strain producing 1-propanol. Additional metabolic engineering of the resulting strain further improved the production of 1-propanol. [This work was supported by the Advanced Biomass R&D Center of Korea (ABC-2010-0029799) through the Global Frontier Research Program of the Ministry of Education, Science and Technology (MEST). Further supports by BioFuelChem, EEWS program of KAIST, and the World Class University program (R32-2008-000-10142-0) of the MEST are appreciated.]. |
| 저자 |
이종언, 천승우, 최용준, 박진환, 김태용, 이상엽
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| 소속 |
한국과학기술원 |
| 키워드 |
생물화공 |
| E-Mail |
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| 원문파일 |
초록 보기 |
