| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
A “Light-up” 1D supramolecular nanorprobe for silver ions based on self-assembly of pyrene-labeled peptide amphiphiles: cell-imaging and antimicrobial activity |
| 초록 |
Herein, peptide amphiphiles consisting of a hydrophobic alkyl chain (linear for 1 or branched type for 2) and hydrophilic histidine-containing peptide, which is known to detect specific metal ions, self-assembled into nanofibers (NFs) in water with a strong aggregation tendency. Particularly, by adopting pyrene as a fluorescent probe, the self-aggregate behavior was investigated based on different optical properties between 1 and 2. Furthermore, 1 shows light-off sensing signal to Cu2+ while 2 increases the fluorescence by capturing Ag+ in aqueous solution. Also, a considerable enhancement of fluorescence in Ag+-NF-loaded HeLa cells was observed. In addition, the NFs of 2 decorated with AgNFs are shown to possess highly effective and long-term antibacterial activity against both Gram-negative and –positive bacteria. This interesting interaction between Ag+ and 2 makes it possible for the biological application of cell-imaging and antimicrobial agents. |
| 저자 |
김인혜1, 정헌호1, 허강무1, 이창수1, 김건희2, 이은지1
|
| 소속 |
1충남대, 2한국기초과학지원(연) |
| 키워드 |
self-assembly; peptide amphiphile; nanofiber; silver ion; biological applications
|
| E-Mail |
|
