| 초록 |
Restenosis and thrombosis are still drawbacks of stent use, that’s why many types of stents have been produced. It is reported that nitric oxide (NO) has anti-restenotic effects. In this study, we focused on trying to reach an optimum coating condition for liposome containing DETA-NONOate, a NO donor, on a coronary stent, which will achieve a long-term sustained release of NO by comparing three main coating techniques; direct coating on metal surface, direct coating on polymer layer, and layer-by-layer coating technique. Layer-by-layer coating accomplished a sustained release of NO for about 5 days with two drug release bursts when compared to the other two coating techniques. In addition, biological studies revealed that samples had least fibrinogen adhesion when compared to control, also due to the sustained release of NO, ECs were maintained for about five days. In vivo tests show that NO stents have has better histological results than BMS when implanted in a porcine blood vessel |
