| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Transdermal permeation of FITC-BSA using microneedle system |
| 초록 |
Penetration rate of large molecule through skin is very low due to the barrier effect of straum corneum. Novel microneedle treatment device with roll was designed for transdermal delivery of large molecular drugs such as vaccine and protein drugs. The permeation rates of FITC labelled boving serum albumin (FITC-BSA) as a model protein were taining FITC-BSA. Fluorescent spectrophotometer was used to analyze the concentration of FITC-BSA in the skin. We confirmed that permeation rate of BSA was increased with the treatment by microneedle and was increased by the increasing frequency of treatment. Furdermore, the permeation rate observed from hydrogel treated skin was significantly higher than that from solution treated skin. |
| 저자 |
박현진, 김윤태, 김혜린, 이종문, 유일수, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
FITC-BSA; Microneedle; Permeation; Transdermal
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| E-Mail |
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