| 초록 |
Fluorescence-related techniques such as in vitro bioassay or in vivo molecular imaging have made significant contributions to advances of life sciences, as powerful tools allowing a closer access to biological processes at the molecular and cellular levels. To realize their potential for advanced researches and clinical uses, a breakthrough in fluorescence signal is demanded over the current levels achieved by organic dyes, fluorescent proteins, dye-loaded nanoparticles, and quantum dots. In this presentation, polymer nanoparticles concentrated with chromophores showing aggregation-enhanced fluorescence are reported as a novel class of high-signal-output nanoprobes. Unprecedented bright fluorescence and efficient intraparticle energy transfer to the co-embedded acceptor, both of which are resulted from the unique high chromophore density, will be demonstrated by various bioimaging applications, with a discussion of new opportunities and future directions in the area of biophotonics. |
