| 초록 |
Mesoporous silica nanoparticles have emerged as attracted nanocarriers in the field of drug delivery and molecular imaging. In this study, we describe novel mesoporous silica nanoparticles bearing pH-responsive charge-convertible pore walls that can facilitate the release of entrapped proteins at a cellular endosomal environment. The mesopore of silica nanoparticles was functionalized with citraconic amide with terminal carboxyl groups. This nanoparticle can hold positive proteins at physiological pH and can trigger selectively the protein release at below endosomal pH (~5.0), caused by conversion of pore surface charges from negative to positive state. These silica-based hybrid nanoparticles can act as efficient intracellular drug delivery systems. Acknowledgement. This research was supported by a grant (code#: 08K1501-01110) from 'Center for Nanostructured Materials Technology' under '21st Century Frontier R&D Programs' of the Ministry of Education, Science and Technology, Korea. |
