| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Strategy to prevent oral bacterial adhesion on hydroxyapatite surface by coating zwitterionic MPC polymer containing calcium-binding moieties |
| 초록 |
The strategy of this study is to develop anti-biofouling interface on hydroxyapatite surface by synthesize a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer capable of being immobilized on the tooth surface. It can be achieved by developing an MPC-based polymer with Ca2+-binding moieties for stronger binding with hydroxyapatite (HA) of the tooth surface. So, a 2-methacryloyloxyethyl phosphate (MOEP) monomer was synthesized and MPC-ran-MOEP (abbreviated as PMP) with varied composition was synthesized by free radical polymerization. The coating efficiency of the polymer onto a HA surface was estimated by means of contact angle measurement and X-ray photoelectron spectroscopy. The anti-biofouling nature of PMP-coated HA surfaces was estimated by analyzing protein adsorption, cell adhesion, and Streptococcus mutans adhesion. |
| 저자 |
강선아1, 이명진2, 이연1, 서지훈2
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| 소속 |
1서울대, 2고려대 |
| 키워드 |
2-methacryloyloxyethyl phosphorylcholine; zwitterion; calcium binding; Streptococcus mutans; anti-biofouling;
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| E-Mail |
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