| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
생체모방형 고분자재료(의료용 고분자 부문위원회) |
| 제목 |
Enhancement of cellular function on RGD peptides immobilized-poly (L-lactide-co-ε-caprolatone) nanofiber using 60Co γ-ray irradiation |
| 초록 |
Biomimetic materials have been developed to improve cellular responses in tissue engineering scaffolds. The main goal of this study is to evaluate cellular function elicited by the nano-structured biomimetic scaffolds. A RGD containing peptide was immobilized to electrospun PLCL nanofibrous scaffold by 60Co γ-ray irradiation. The surface characteristics of the electrospun nanofibrous scaffolds were investigated by ATR and ESCA. The cellular function on the nanofibrous scaffold was examined using MC3T3-E1 osteoblast cells. Cellular responses on the RGD immobilized PLCL nanofibrous scaffold were significantly increased in cell adhesion and proliferation as well as ALP activity, protein, and gene expression. These results indicate that the biomimetic materials eliciting desirable cellular responses can be fabricated by γ-ray irradiation, which may provide a useful source for designing scaffolds. |
| 저자 |
신영민1, 임윤묵2, 노영창2, 이영무1, 신흥수1
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| 소속 |
1한양대, 2한국원자력(연) |
| 키워드 |
Biomimetics; PLCL; RGD; γ-ray
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| E-Mail |
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