| 학회 |
한국화학공학회 |
| 학술대회 |
2013년 봄 (04/24 ~ 04/26, 광주 김대중컨벤션센터) |
| 권호 |
19권 1호, p.712 |
| 발표분야 |
재료 |
| 제목 |
Versatile graphene oxide encapsulated Fe3O4 nanoparticles: Application to highly sensitive fluorescence turn-on biosensor |
| 초록 |
Fe3O4@GO hybrids were synthesized by electrostatic force between amine functionalized Fe3O4 nanoparticles(NPs) and GO sheets. Negatively charged graphen oxide(GO) sheets readily attached onto the surface of positively charged magnetic NPs by electrostatic self-assembly. Fe3O4@GO NPs possess not only excellent ferromagnetic properties but also GO’s unique properties. In this work, Fe3O4@GO NPs were used as fluorescent quenchers of aptasensors which show high sensitivity and selectivity. Fluorescent aptamers show high affinity to targets leading to turn on fluorescence and get easily adsorbed on the surface of Fe3O4@GO NPs via π-π interaction in the absence of targets, resulting in quenching of fluorescence. Magnetic separation of Fe3O4@GO NPs enables to increase the sensitivity of biosensors by removing non-binding aptamers and other residues from aqueous solution. |
| 저자 |
최 훈, 김명수, 이강택
|
| 소속 |
연세대 |
| 키워드 |
graphene oxide; mangetic nanoparticle; aptasensor; thrombin; detection
|
| E-Mail |
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| 원문파일 |
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