| 초록 |
N-Acetyl-L-cysteine (NAC) is an anti-inflammatory and anti-oxidant drug used in a broad range of clinical applications such as neuroinflammation, AIDS, and diabetes. The NAC treatment could block the induction of inflammatory related molecules such as TNF-α, IL-1, IFN-γ, and CD11b in primary microglia, which are correlated to the activation of microglial cells in various neuroinflammatory diseases. To date, NAC has required useful drug delivery systems because of low bioavailability. In this study, we suggested that pore surface-functionalized mesoporous silica nanoparticles (MSN) act as a potential carrier for NAC to target neuroinflammation. These MSNs have large surface areas and pore volumes, and thus can deliver a large amount of drug molecules. NAC could be conjugated with disulfide bonds in the pore of MSNs. The release of NAC from the MSNs could be triggered by the intracellular glutathione level, whereas efficiently inhibited at an extracellular glutathione concentration. |
