| 초록 |
Despite the tremendous progress that Photothermal therapy (PTT) has recently achieved, it is still a long way to go to gain the effective targeted photothermal ablation of tumor cells. Driven by this need, we describe a new class of targeted photothermal therapeutic agents for cancer cells with pH responsive bio-imaging using near-infrared(NIR) dye IR825, conjugated poly(ethylene glycol)-g-poly(dimethylaminoethyl methacrylate) (PgP) and hyaluronic acid (HA) anchored reduced graphene oxide (rGO) hybrid nanoparticles. The obtained rGO nanosheets (PgP/HA-rGO) showed pH-dependent fluorescence emission and excellent NIR irradiation of cancer cells targeted in vitro and in vivo photothermal cytotoxicity. In an area of limited successes in cancer therapy, our translation will pave the road to design stimulus environment responsive targeted PTT agents for the safe eradication of devastating cancer. |
