| 초록 |
The silk has been widely used as a potential biomaterial. Silk has low immunity, high. In this study, we fabricated the silk based scaffolds with 1, 2, and 3% were produced by Freeze-dried. And we confirm characteristics of Silk-fibroin scaffold by FT-IR, Compressive strength, SEM, and electrophoresis. Also were performed the cell adhesion and proliferation assay for applicability of silk-fibroin scaffold for wound healing. In vivo inflammatory responses surrounding the implants was performed at 2 or 4 weeks after implantation. The goal of this study is to demonstrate the comparison between the silk-fibroin scaffold and inflammatory in vitro and in vivo. As a result, this study suggests that silk-fibroin scaffold of easy producing and developed in this study has possibility of applications for future used on wound healing. This research was supported by the Brain Korea 21 PLUS Project, NRF, Bio-industry Technology Development Program(KMFAFF, 112007-05-2-SB010). |
