| 초록 |
Nitric Oxide (NO), an essential gas molecule plays a role in wound healing, neurotransmission and immune system depending on its concentration. Therefore, NO delivery with controllable ways is promising and challengeable study. In this study, we introduced graphene oxide (GO) as NO carrier due to its higher surface area and capping property of gas molecules. The amine-functionalized GO (fGO) was prepared by conjugating three kinds of amine source; diethylenetriamine (DETA), tetraethylenepentamine (TEPA) and pentaethylenehexamine (PEHA). Through the reaction with NO gas, secondary amine turned into NO donor. Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) were used for investigated fGO. NO release amount was proportional to the number of secondary amine groups of each molecule and conjugation efficiency. Then, the multilayer structures was prepared by Layer-by-Layer (LbL) assembly and obtained NO release profiles by nitric oxide analyzer (NOA). |
