| 학회 | 한국공업화학회 |
| 학술대회 | 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 | 24권 1호 |
| 발표분야 | [정밀화학] 정밀화학 연구 동향 및 전망 |
| 제목 | Synthesis of heterocycles via oxidative activation on benzylic sp3 carbon |
| 초록 | In recent years, the oxidative cross-dehydrogenative coupling (CDC) have become a topic of interest because the couplings avoid extra prefuctionalization of substrates. In CDC reactions, direct functionalization of C-H bonds build C-C or C-heteroatom bonds and it offers benefits owing to atom-economy and environmental sustainability. Thus, an oxidative CDC is attractive synthetic tool for a heterocycles. Among heterocycles, quinazolinones and quinolones are widely found in natural products and synthetic pharmaceuticals. They are key structure motifs for a wide range of biological properties. On the other hand, quinoxalines have been applied in functional material due to their photophysical properties. Herein, we present a direct synthesis of these heterocycles using unfunctionalized methyl arenes and alcohols as the accessible starting materials. |
| 저자 | 홍석창 |
| 소속 | 서울대 |
| 키워드 | cross dehydrogenative coupling; benzylic carbon; quinazolinone; quinolone; quinoxaline |
