| 학회 |
한국공업화학회 |
| 학술대회 |
2014년 가을 (11/12 ~ 11/14, 엑스코(대구)) |
| 권호 |
18권 2호 |
| 발표분야 |
나노-포스터 |
| 제목 |
Tumor-targeted delivery of siRNA using stabilized calcium phosphate nanoparticles using dopa-hyaluronic acid conjugate |
| 초록 |
Low cytotoxicity and high cellular gene delivery capability are among the most important prerequisites for the selection of a non-viral carrier. Although calcium phosphate (CAP) nanoparticles have been long used for animal cell transfection, its rapid and uncontrollable crystal growth and lack of tissue specificity are among the most challenging problems that limit its use in the clinic. In this study, we report the development of CAP nanoparticles stabilized by a conjugate of the mussel-inspired adhesive molecule, 3,4-dihydroxy-l-phenylalanine (dopa), and a nontoxic hydrophilic natural polymer, hyaluronic acid (HA), for targeted siRNA delivery to tumors. |
| 저자 |
이민상1, 이정은1, 변은경2, 김낙원1, 이해신2, 정지훈1
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| 소속 |
1성균관대, 2한국과학기술원 |
| 키워드 |
3; 4-Dihydroxy-l-phenylalanine; Calcium phosphate nanoparticle; Gene delivery; Hyaluronic acid; Targeted delivery
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| E-Mail |
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