| 초록 |
Molecular self-assembly has been attracting great interest in the fields of chemical biology and material science because of its potential to build nanostructured materials with advanced properties and performance. In particular, to emulate the structure and function of live cells or natural extracellular matrices in biological systems, efforts are increasingly being made for molecular, nano-, and micro-scale design of bio-inspired molecules. Specifically, this presentation covers synthesis of a bioactive hyperbranched polyglycerol (HPG) that can modify cell surfaces with inflammatory vasculature binding peptides (VBPs) via in situ self-assembly with cells. Additionally, we demonstrate the stem cells engineered with the bio-functionalized HPG can anchor to target defective vasculature. The overall process is analogous to the way in which leukocytes are mobilized to the injured endothelium. We propose that the resulting bioactive HPG-based cell carrier would be highly useful for guiding a wide array of therapeutic cells to target tissue and improving efficacy of cell therapies. |
