| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Development of polyamine-based nanoparticles for small interfering RNA delivery to hepatic cells |
| 초록 |
Small interfering RNA (siRNA) can mediate a powerful gene-silencing for treatment of varied diseases. Polyamines could be used to synthesize siRNA delivery materials due to their cationic characteristics. Here we developed polyamine-based lipid-like nanoparticles for siRNA delivery to human hepatic cells. Alkyl-epoxides were conjugated to several polyamines through ring-opening reactions. In a reporter siRNA delivery experiment, among polyamines spermine was found to be effective for siRNA delivery to human hepatic cells. When spermine-based nanoparticles were tested for delivery of siRNA targeting a host enzyme, PRK2, which is required for hepatitis C virus replication, they mediated significant silencing of the target enzyme expression in human hepatic cells. This work was supported by a grant (10035159-2010-01) funded by the Ministry of Knowledge Economy, Korea. |
| 저자 |
박현지1, 강성민2, 박성해1, 유성열1, 오종원1, 이해신2, 조승우1
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| 소속 |
1연세대, 2한국과학기술원 화학과 |
| 키워드 |
siRNA; nanoparticle; delivery
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| E-Mail |
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