| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
세포기능조절 고분자(의료용 고분자 부문위원회) |
| 제목 |
Potentialities of Fibrin on Reduction of Inflammatory Reaction of PLGA |
| 초록 |
In this study, we evaluated the effect of fibrin as a natural material on the local inflammatory reaction of PLGA in vivo. PLGA degradation products can decrease the pH in the surrounding tissue, which result in local inflammatory reaction. To complete disadvantage on implantation of PLGA, Fibrin/PLGA scaffolds were implanted in 5-week-old Wister rats. To evaluate the influence of fibrin content in PLGA materials on inflammatory cytokine expression, RT-PCR used. Fibrous wall thickness and macrophage were evaluated by H&E and ED-1 immunohistochemical staining, respectively. In this study, we showed that fibrin/PLGA scaffolds reduction of inflammatory reaction were superior to PLGA scaffold in terms of reduction of inflammatory reaction. We concluded that fibrin could reduce inflammatory response of PLGA. This research was supported by SCRC(SC4110)and WCU(R31-20029) |
| 저자 |
정선영, 김수진, 고마음, 김혜린, 송재은, 유동혁, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
fibrin; PLGA scaffold; inflammatory cytokine; in vivo
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| E-Mail |
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