| 초록 |
Poly(lactic-co-glycolic) acid (PLGA) is one of the most successfully developed biodergradable polymers. Articane is the most widely used local anesthetic in contemporary dentistry. In this study, PLGA and articaine-loaded PLGA nanofiber were prepared by using electrospinning process. PLGA and articaine were dissolved in a solvent (Tetrahydrofuran(THF):Dimethyl formamide(DMF)=3:1) and high voltage is applied to the liquid to produce charged liquid zet. The zet is elongated by electrostatic repulsion which leads to the formation of nanofibers. Nanofibers were prepared with needle size, applied voltage, and solvent flow of 23G, 23kV, 1.5ml/h, respectively. The surface morphology of the fibers were characterized by scanning electron microscopy (SEM). The PLGA/articane nanofiber had both smooth and rough surface with an average diameter of 670±30nm. The release rate of articaine was also investigated by using an UV/Vis. spectrometer. |
