| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
In Vitro and In Vivo Evaluation of Dual Growth Factor-Immobilized Microparticles for Nerve Regeneration |
| 초록 |
The use of stem cells that can be expanded to high cell numbers as well as differentiated into neuronal cells is a rapidly emerging field for the regeneration or reconstruction of nerves. However, their insufficient differentiation into neuronal cells and poor long-term survival in the body still remain as major obstacles. In this study, we developed dual growth factor (GF; NGF and bFGF)-immobilized polycaprolactone (PCL) microparticles to prolong the cell stability in the applied site (by microparticles as a cell carrier) and enhance the neuronal differentiation of stem cells (by sustained release of GFs). The induction potential for neuronal tissue by the GFs released from the microparticles was evaluated. We observed that dual GF-immobilized micropatricle groups allowed greater neurogenesis of the stem cells (in vitro) and faster nerve regeneration (in vivo) than the control (w/o GF) and single growth factor groups. |
| 저자 |
안단비1, 김태호1, 오세행2, 이진호1
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| 소속 |
1한남대, 2단국대 |
| 키워드 |
neurogenesis; micropatricle; stem cells
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| E-Mail |
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