| 학회 | 한국화학공학회 |
| 학술대회 | 2011년 가을 (10/26 ~ 10/28, 송도컨벤시아) |
| 권호 | 17권 2호, p.1719 |
| 발표분야 | 열역학 |
| 제목 | High-Pressure Phase Behavior of Adefovir Dipivoxil in Supercritical Carbon Dioxide |
| 초록 | Adefovir dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection. Adefovir dipivoxil was approved by the US FDA in 2002 for the treatment of chronic hepatitis B. It is also active on viruses such as CMV(Cytomegalovirus). For pharmaceutical purpose, adefovir dipivoxil were recrystallized into nano size particle. The recrystallized adefovir dipivoxil particles can be used various pharmaceutical researches. For getting more effectiveness and setting suitable process parameters of RESS(Rapid Expansion of Supercritical Solutions) experiment, we measured solubility data of adefovir dipivoxil in supercritical carbon dioxide. In this study, the cloud points of adefovir dipivoxil in supercritical carbon dioxide were investigated as functions of pressure, temperature, and concentration of adefovir dipovoxil. We measured cloud points of adefovir dipivoxil in supercritical carbon dioxide using the high-pressure variable volume view cell apparatus. The high-pressure phase behavior of adefovir dipivoxil in supercritical carbon dioxide were observed ateach concentration 0.1 - 1.0 wt %. |
| 저자 | 김형건1, 임준혁1, 김우식2, 유기풍1, 임종성1 |
| 소속 | 1서강대, 2경희대 |
| 키워드 | Adefovir Dipivoxil; cloud point; supercritical |
| 원문파일 | 초록 보기 |
