| 초록 |
Among the visible light, short wavelength like blue light can be widely used in photomedicine due to high energy. However, there are some limitations to biomedical application when that is irradiated on the skin because of low penetration into tissue. To resolve these issues, we developed transdermal delivery system using hyaluronic acid (HA) based nanocarriers encapsulating up-conversion (UC) dye as light source, which can convert light with low energy (red) into high energy (blue). The successful preparation of nanocarriers was confirmed by DLS and TEM, and the encapsulation of UC dye and stability were confirmed by the UV-Vis spectrometer. Furthermore, the successful permeation and blue light emission were confirmed as well in the skin permeation test for 24 hours on porcine skin. With these results, we could resolve the limitation of short wavelength with low penetration for the effective phototherapy in skin. |
