| 초록 |
Nanoscopic delivery vehicles capable of encapsulating drug molecules and releasing them in response to external stimuli are of great interest due to implications in therapeutic applications. For this purpose, we have developed a facile synthetic method for highly stable, polymeric nanogels using a simple intra/inter-chain crosslinking reaction. We show a simple, emulsion free method for the preparation of biocompatible nanogels that provides the ability to encapsulate hydrophobic guest molecules. The resulting nanogels show sizes of several hundred nanometers with well-defined shapes. The nanogel surfaces can be functionalized with specific groups, allowing for potential functionalization for targeted delivery. Hence, the reversible nanogel formation using self crosslinking polymers and the corresponding method of surface modification are a promising platform for creating polymer nanogels for a range of biomedical applications, from drug delivery to bionsensing. |
