| 초록 |
Gene therapy has been attracted a lot of interests because of its potentials to treat various incurable diseases such as cancer and viral disease. Especially, siRNA based target gene knockdown approaches have been expected as a powerful therapeutic tool due to broad accessibility to control the expression of various disease relevant proteins compared to small molecular drugs. However, there are several requirements to elicit therapeutic effect in clinical trials. To fulfill these prerequisites, there have been various approaches using several kinds of materials including nanoparticles, liposomes, and polymers. Among them, mesoporous silica nanoparticle might give some opportunities to develop delivery vehicle due to its biocompatibility, structural robustness, and easy surface modification through silane coupling. Here, we report an intracellular siRNA delivery system enabling simultaneous MR imaging and gene therapy using mesoporous silica nanoparticle possessing large pores. |
