| 초록 |
Hydrogel for biomaterials need to good mechanical property like a tissue. But, usually natural hydrogels have a low mechanical property. Therefore, biocompatible polymer based double-network (DN) hydrogel with high toughness and biocompatibility have been good application as biomaterials. In this study, we synthesized a double crosslinking alginate/poly (vinyl alcohol-co-acrylamide) through a two-step process. First network, sodium alginate (SA) as grafted to the dopamine (DA) and then add to natural extracts. Second network, P(VA-AM) was conjugation with first network by schiff base reaction. Also, crosslinking agents used ammonium persulfate, and N,N'-methylenebis-acrylamide to form SA-DA/P(VA-AM) DN hydrogel. Finally, the chemicophysical properties of the DN hydrogel was confirmed by mechanical properties, swelling ratio, Field-Emission Scanning Electron Microscopy (FE-SEM), Fourier Transform Infrared Spectroscopy (FT-IR), MTT assay, Thermogravimetric Analysis (TGA). |
