| 초록 |
Polymer gold nanoshells (PGNs) are synthesized by a novel plant-inspired molecule. Pyrogallol 2-aminoethane (PAE) is a synthetic analog of tannin acid, which is known to have a high binding affinity with various noble metals, proteins, and oxides. Various polymeric nanoparticles were surface-modified with PAE and gold nanoshells were generated upon the addition of gold salt precursor solution. Due to reductive nature of PAE, gold seed growth on polymeric nanoparticles followed by gold plating can be easily achieved. Prepared PGNs show high photothermal properties in which are suitable for externally triggered release of siRNAs into the cytoplasm of cells. Efficient gene silencing has been achieved using siRNA immobilized PGNs, suggesting the potential applications of in vitro gene regulation by an external NIR stimulus. |
