| 초록 |
To overcome the cytotoxicity of polyethyleneimine (PEI) in vivo, the biodistribution and clearance of PEI conjugated with near-infrared fluorophores (NIRF) were imaged in mice. PEI was conjugated with three different types of NIRF (NIRF+, NIRF-, and NIRF±) to confirm the effect of the surface charge of PEI for enhanced renal clearance. The zwitterionic PEI-NIRF± conjugate was found to be rapidly cleared, primarily through the kidneys of the mice, within 24 h postinjection. Thus, zwitterionic PEI-NIRF± could be a promising gene delivery carrier that can potentially reduce the side effects of conventional cationic polymers such as cytotoxicity and non-specific binding in vivo. |
