| 초록 |
Various strategies about nanoparticles have been extensively investigated for targeted tumor therapy as the promising drug carrier, delivering anti-cancer drug. However, the limitation of delivering drug to the core of solid tumor is rest, resulting in tumor relapse and low therapeutic efficacy. In order to improve its overall therapeutic outcomes, we designed tumor microenvironment-responsive size-convertible nanoparticles (TSNPs) including pH-responsive polymeric shell which bares doxorubicin-conjugated gold nanosatellites (DOX-GNSs) in the core. Through demicellization of TSNPs at the mildly acidic (pH 6.5-6.8) condition of tumor ECM, the release rate of DOX-GNSs from the TSNPs increases rapidly. DOX-GNSs have capability to penetrate deep tissue due to their nano-size ( ＜ 3 nm). Overall, TSNPs showed a great potential as a drug carrier for cancer therapy. |
