| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Preparation of supramolecular polymeric micelles via host-guest interaction |
| 초록 |
We have synthesized pseudo-block copolymer from β-cyclodextrin terminated poly(N-acryloylmorpholine) (PNAM) and adamantine (AD)-terminated linear poly(DL-lactide), through host-guest interaction between β-cyclodextrin and adamantine groups. The synthesized polymers were characterized by 1H NMR, GPC and FTIR. The critical micellar concentration (cmc) of this pseudo-block copolymer was determined by fluorescence spectroscopy using pyrene as a probe. Formation of the supramolecular micellar nanoparticles were confirmed by means of DLS and TEM. A hydrophobic drug, Doxorubicin was chosen as a model drug to study the potential application of this pseudo-block copolymer in controlled drug release. The results indicated that the release rate of Doxorubicin-loaded micelles at pH 6.4 was faster than that at pH 7.4 |
| 저자 |
임권택, Kalyan Ramesh, Daru Seto Bagus Anugrah, 홍성수, 이근대
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| 소속 |
부경대 |
| 키워드 |
Critical micellar concentration; Supramolecular micelles; Drug delivery; Host-guest
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| E-Mail |
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