| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Super cationic nanofibrous mesh for surface modification |
| 초록 |
Electrospun nanofibers offer the opportunity to enhance cell attachment because their intrinsic structures are similar to those of the extracellular matrix. However, poly(ε-caprolactone)(PCL) nanofiber has limitations of cellular adhesion due to their high hydrophobicity. Polyethylenimine(PEI) was conjugated to PCL to prepare highly charged surfaces of primary amine groups. PCL-PEI diblock copolymers were synthesized by conjugating PEI to the terminal hydroxyl groups of PCL. PCL was acrylated with acryloyl chloride in the presence of triethlyamine in benzene. After 12h, acrylated PCL in DCM were added to PEI by a drop-by-drop manner. PCL-PEI block copolymer was characterized by 1H-NMR and the number of primary amine was quantified by fluorescamine assay. The diblock copolymer was electrospun to nanofiber. The cationic density on the surface was adjustable by attaching non-ionic and hydrophilic molecules on the surface of the nanofiber. |
| 저자 |
강지현, 최지숙, 김혜성, 손영주, 윤수진, 조은주, 김영희, 유혁상
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| 소속 |
강원대 |
| 키워드 |
block copolymer; polycaprolactone; polyethyleneimine
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| E-Mail |
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