| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Development of novel cationic polymer carrier for siRNA delivery |
| 초록 |
Polymeric non-viral carriers have advantages such as convenience of handling and flexible gene loading capacity over viral vectors. Despite these advantages, their applications to human gene therapy are still limited because of their cytotoxicity and low transfection efficiency. To overcome these limitations, novel cationic and biodegradable polymer (Methoxypoly(ethylene glycol)-b-poly{N-[N-(2-aminoethyl)-2-aminoethyl]-L-glutamate} (PEG-b-PNLG) was synthesized for gene delivery. A series of PEG-b-PNLG polymers having different molecular weights of PEG and side chain lengths of PNLG were used to deliver siRNA by forming nanocomplexes through electrostatic interations. These nanocomplexes enhanced the cellular uptake of siRNA, resulting in greater transfection efficiency compared with bPEI/siRNA complex. So, these novel cationic polymers can be used as effective non-viral polymeric carrier for siRNA delivery. |
| 저자 |
서영규, Yi Li, 이민상, 정지훈, 이두성
|
| 소속 |
성균관대 |
| 키워드 |
cationic polymer; siRNA delivery; polymer carrier; gene delivery
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| E-Mail |
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