| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Evaluation of an in situ forming N-hexanoyl glycol chitosan hydrogel for wound healing |
| 초록 |
An in situ forming hydrogel was prepared from N-hexanoyl glycol chitosan and investigated for applications of wound healing. It can be prepared by simple method without using additional cross-linking process. The cytotoxicity and biodegradability of N-hexanoyl glycol chitosan were evaluated and found non-toxic and biodegradable. The sol-gel transition of N-hexanoyl glycol chitosan well controlled from 23 to 56℃ at a low concentration (3-7 wt%) depending on the degree of hexanoylation (DH) and concentration of polymer solution. When observed by electron microscopy, the N-hexanoyl glycol chitosan based hydrogel had a highly porous structure. The wound healing efficacy of hydrogel was evaluated with mice excisional wound model. It was found that the wound covered with gel was filled with new epithelium without any significant adverse reactions and capable of enhancing wound healing. Therefore N-hexanoyl glycol chitosan hydrogel may applied an effective and safe for wound healing. |
| 저자 |
이정정1, 권보선2, 김세희2, 심혜은2, 황준석1, 허강무1
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| 소속 |
1충남대, 2우리들생명과학 |
| 키워드 |
chitosan; hydrogel; wound healing
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| E-Mail |
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