| 학회 | 한국화학공학회 |
| 학술대회 | 2007년 봄 (04/19 ~ 04/20, 울산 롯데호텔) |
| 권호 | 13권 1호, p.432 |
| 발표분야 | 생물화공 |
| 제목 | Electrochemical anti-cancer drug effect detection using cyclic volatammetry techniques |
| 초록 | The biological surfaces were fabricated for the immobilization of cancer cell (HepG2) using self-assembled peptide (CRGD-MAP). Cancer cells were immobilized and cultured on the designed oligopeptide SA layer. SPR and AFM study showed the thin film fabrication and immobilization of HepG2 on CRGD layer. The exposure to anti-cancer drugs activates the apoptotic signaling pathway induced to change the biochemical integrity of immobilized cells, resulting in decreasing the current of cyclic voltammogram. Aknowledgement This work was supported by the korea Science and Engineering Foundation (KOSEF) through the Advanced Environment Monitoring Research Center at Gwangju Institute of Science and Technology and by the Nano/Bio science & Technology Program (M10536090001-05N3609-00110) of the Ministry of Science and Technology (MOST) and by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government(MOST) (M1064408000306N440800310). |
| 저자 | 예철헌, 이범환, 전승준, 최정우 |
| 소속 | 서강대 |
| 키워드 | cell immobilization; cancer cell; surface plasmon resonance; cyclic voltammetry; cell chip |
| 원문파일 | 초록 보기 |
