| 학회 |
한국공업화학회 |
| 학술대회 |
2007년 봄 (05/11 ~ 05/12, 계명대학교) |
| 권호 |
11권 1호 |
| 발표분야 |
정밀화학 |
| 제목 |
Preparation of core-shell type MBHA resin and its application to Solid-Phase Peptide Synthesis |
| 초록 |
MBHA(4-methylbenzhydrylamine) resin has been widely used for the synthesis of peptide amides and its industrial demand as a solid support for the production of peptide drugs is increasing. We prepared MBHA resin by benzotriazole-catalyzed amidoalkylation. First, formamido PS was synthesized from 1% DVB-PS using bis-formamide and benzotriazole. By removing formamido group, MBHA resin was obtained. The core-shell type MBHA was also constructed by partial hydrolysis of the formamido groups. It was analyzed by confocal microscopy and its synthetic performance in SPPS was evaluated. |
| 저자 |
최정현, 이태경, 이윤식
|
| 소속 |
서울대 |
| 키워드 |
MBHA resin; Core-shell-type; Amidoalkylation; Benzotriazole; Solid-phase peptide synthesis
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| E-Mail |
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