| 초록 |
Verteporfin is an efficient photosensitizer (PS) for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as macular degeneration. It has a much longer excited wavelength (693 nm) for deeper tissue penetration than other PSs. In this study, the vertepotfin carrier for other tumor therapy was developed by designing multifunctional and biodegradable block copolymer-gold nanoparticle (AuNP) conjugates, which act as a water-soluble and biocompatible carrier that allows delivery of a hydrophobic PS to tumor site for PDT action. The FA-PEG-P(Asp-Hyd)-DHLA-modified AuNPs became so stable that their optical property did not change under very harsh conditions. Then, hydrophobic PSs were conjugated to the stable vectors through pH-sensitive linkage. The particle size, size distribution, and morphology of FA-PEG-P(Asp-Hyd)-DHLA-modified AuNPs were investigated. |
