Conventional active islanding detection methods (IDMs) are designed for the inverter-based distributed generation systems (DGSs) with current control interface. Such strategies can hardly be extended to the DGS with power control interface because the power control loop can affect the IDMs by enlarging the nondetection zones (NDZs). This paper presents an active IDM based on negative-sequence power injections for the DGS with power control interface. Combining with the IDM, the power control of the DGS is achieved with two control loops. One is the positive-sequence power loop that satisfies the conventional power control requirements. The other is the negative-sequence power/current variation loop for the islanding detection. The positive and negative sequences are separated by a simple strategy based on an all digital phase-locked loop. Due to the differences between the grid impedance and the local load impedance, the percentage of the voltage imbalance (VI) at the point of common coupling is utilized to indicate the islanding operation. For the grid-connected DGS, the VI is dominated by the grid voltage, which is a constant. If the DGS is disconnected from the grid, the VI is determined by the injected negative-sequence power/current. The NDZs of the presented scheme with different system configurations, such as grid impedances, load quality factors, etc., are also analyzed in this paper. By injecting the negative-sequence power/current periodically, the NDZs resulting from the imbalance of the grid voltages or the local loads are further mitigated. For multi-DGSs, the IDM is still effective if combined with the conventional under/overfrequency-protection strategy. The simulation and experimental results verify the effectiveness of the IDM.