A rapid assay procedure based on high-performance liquid chromatography (HPLC) has been developed for the specific determination of antihypertensive drug felodipine in pharmaceutical formulation (tablets). The HPLC determination was carried out on a reversed-phase C-18 (250x4.6 mm i.d) column using a mobile phase consisting of acetonitrile 20 mM aqueous ammonium acetate buffer of pH 4.5 (80+20) at a flow of 1.0 mL min(-1) with UV defection at 236 nm. Calibration graph was linear from 2.49 to 99.60 mug mL(-1). The method has been validated according to current guidelines including the assay of pharmacopoeial standard tablets. Recoveries ranged from 97.80 to 102.10%. The excipient present in the tablets did not interfere in the method. The described HPLC method is comparable in terms of accuracy and precision with that of a reported method.