This paper focusses on tile design of Dynamic Matrix Control (DMC) for non-linear systems in real time using Matlab and dSPACE interfacing card. A pH neutralization and quadruple tank process are considered here for predictive control, based on the system matrix formulation Using data obtained from real time, for which, linear optimization based constrained Controller design is performed. The controller effort weighing (,) and number of predictions steps (P) are tuned for tile systems in real time. The systems are analyzed for reference tracking, and disturbance rejection behaviour.