A simple, sensitive and accurate UV spectrophotometric method has been developed for the determination of eprosartan mesylate in raw material and experimental tablets. Beer's law was obeyed in the concentration range 2-30 mu g mL(-1) for the drug (k 232 nm) with an apparent molar absorptivity and Sandell sensitivity of 2.8 x 10(4) L.mol(-1)cm(-1) and 0. 01854 mu g cm(-2)/0.001A, respectively. The limits of detection and quantitation were calculated to be 0.3623 and 1.098 mu g mL(-1), respectively. Results were validated statistically according to ICH guidelines. Validation of the method yielded good results in the concerning range (2-30 mu g mL(-1)), linearity (r(2) = 0.9998), precision and accuracy. The excipients present in the experimental tablets did not interfere with the method.