A novel approach to solution of a one-dimensional and two-region, parabolic moving boundary problem in spherical coordinates was presented. The problem, known as parabolic Stefan problem, takes place in the vacuum freeze drying of the disordered porous materials for example biomaterials or pharmaceuticals. It is adequate for lyophilization process of the material frozen on inner wall of the spherical glass bulb. Such a method of vacuum freeze drying is utilized in biosynthesis products preservation.