A fibrin-free intraocular lens (IOL) has been developed for hindering secondary cataract. Hydrophilic and hydrophobic micro-domains were alternately generated on the poly(methyl methacrylate) [PMMA] IOL surface with UV photon irradiation. The modified IOL was soaked in aqueous fibrin solution, and the fibrin adsorption was measured by infrared spectroscopy (FT-IR). The results show that the fibrin adsorption on the sample with hydrophilic groups increased, while that on the sample with hydrophobic groups decreased. Moreover, the fibrin adsorption on the sample surface with hydrophilic and hydrophobic micro-domains arranged alternately was reduced to one-fifth of that on the untreated sample.