From a molecular perspective, the fundamental rolling and sliding elasto-adhesion interactions between a spherical nano-particle and an elastic substrate is studied using a computational technique based on the Molecular Dynamics (MD) approach. Initially, the particle and the substrate were equilibrated individually at 300 K. The covalent bonds interactions between the atoms of the nanoparticle are modeled by constraining the atoms to stay together throughout the simulation. The temperature of the substrate atoms is regulated by periodically scaling to mimic the bulk substrate effect to minimize the effects of the finite substrate size. The intermolecular interaction between the particle and the substrate is defined by the Lennard-Jones (LJ) 12-6 potential. The total force-displacement curves of the 4.2 and 7.89 nm particles in the cases of particle being pushed normally towards the substrate and the particle pushed tangentially, while in adhesion with substrate, are obtained. The rolling resistance moment exhibited by the smaller nanoparticle (4.2 nm) is calculated from the force-displacement curve obtained from simulations and compared to the theoretical predictions based on a two-dimensional adhesion model. It is found that the moments as a function of the rotation angle. are of the same order (3.64. nN nm). The rolling and sliding force-displacement profiles when the nanoparticle is subjected to tangential load are also presented. (C) Koninklijke Brill NV, Leiden, 2009