The adsorption of nitrous oxide (N2O) on silicalite-1 has been investigated using a volumetric method. The adsorption isotherms are for the first time reported at temperatures in the range of 273 K to 398 K and at pressures up to 120 kPa. The Langmuir isotherm appropriately fits the equilibrium data. The thermodynamic properties such as the Henry's law constant and enthalpy associated with the adsorption are derived to characterize interactions between adsorptive and adsorbent.