A flow-type isothermal microcalorimeter was used to measure excess enthalpies, H-E, of the binary mixtures of ethanol + acetone, + octane, + cyclohexane and 1-propanol + acetone, + octane, + heptane at 323.15 K at atmospheric pressure. The experimental results show that the excess enthalpies of these systems are all endothermic over the entire composition range, and their maximum values of H-E are in a range of 946.9 J(.)mol(-1) to 1549.4 J(.)mol(-1). The data were correlated with a modified Redlich-Kister equation to within experimental uncertainty, except for 1-propanol + acetone.