The solubility Of CO2 in aqueous solutions, 18 mass %, 25 mass %, and 30 mass % (2.0 M, 2.8 M, and 3.4 M), of 2-amino-2-methyl-1-propanol (AMP) has been measured over a temperature range of (303 to 323) K and a partial pressure range of (1 to 100) kPa. In this work, the modified Clegg-Pitzer equation is used to correlate and predict the vapor-liquid equilibria of the (CO2 + AMP + H2O) system. The model predicted results are in good agreement with the experimental vapor-liquid equilibrium (VLE) measurements in this work. A nontraditional optimization algorithm, simulated annealing (SA), has been used for the parameter estimation. It is observed that adopting the SA technique for the estimation of interaction parameters results in better VLE prediction accuracy than using the traditional deterministic techniques, such as Levenberg-Marquardt.