The structure-H hydrate of cis-1,4-dimethyleyclohexane in the presence of methane was investigated in the temperature range 274.1 to 287.9 K and the pressure range 1.62 to 9.13 MPa. cis-1,4-Dimethylcyclohexane in the presence of methane was enclathrated into the largest cage of the structure-H hydrate, while trans-1,4-dimethyleyclohexane was not enclathrated. The present study reveals that cis-1,4-dimethylcyclohexane as well as 1,1- and cis-1,2-dimethylcyclohexanes can generate the structure-H hydrate with the help of methane.