Electromotive forces of cells without liquid junctions K-ISE \ CsCl(m(E)) \ ISE-Cl and K-ISE \ CsCl(m(E)), glucose(m(S)) \ ISE-Cl have been measured at 5 K intervals from T = 278.15 to 313.15 K, where m(E) = (0.001 to 0.1) mol kg(-1) and m(S) = (0.01 to 3.0) mol kg(-1). The activity coefficients of CsCl in glucose + water solutions can be obtained from these electromotive force data; in the meantime, the interaction parameters of the CsCl + glucose pair in water, g(EN), h(EN), s(EN), and c(p,EN), can be evaluated. We show that g(EN) > 0, h(EN) > 0, s(EN) > 0, and c(p,EN) < 0 at all four temperatures (except for h(EN) and s(EN) at T = 313.15 K), and the values of g(EN), s(EN), and c(p,EN) vary slightly with temperature, whereas the values of h(EN) is very sensitive to the temperatures used. These thermodynamic parameters were discussed in terms of a model of the structural interaction and electrostatic interaction and were analyzed by the group additivity principle.