Supercritical fluid extraction is a potential technique for the purification of pharmaceutical products containing residual solvents. The solubilities of the drugs in supercritical carbon dioxide are being measured as part of a program in which the potential applications of this technology are being investigated. The solubilities of six 1,4-dihydropyridine derivatives in supercritical carbon dioxide were reported at temperatures from (338 to 358) K and in the pressure range of (12.2 to 35.5) MPa. Results showed that solubilities increase linearly with increasing density at constant temperature and increase with increasing temperature at constant density. The measured solubilities were correlated using a semiempirical model.