Experimental results are reported for the solubility of ceftriaxone disodium in acetone, methanol, ethanol, formamide, and N,N-dimethylformamide between 278 and 318 K. The isothermal method and the laser monitoring observation technique were used for the determination of the mole fraction concentration. The solubility of ceftriaxone disodium in pure solvents increases with increasing temperature and in the following order: acetone < ethanol < N,N-dimethylformamide < methanol < formamide. The experimental solubility data were correlated with a semiempirical equation.